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Typhoid IgG/IgM Rapid Test CE Marking


Product Number: RAPG-TPH-001 (Serum, Plasma)
Product Number: RAPG-TPH-002 (Serum, Plasma, Whole Blood)

Pack size

20 tests

Product Description

Typhoid rapid test The Biopanda Typhoid IgG/IgM Rapid Test detects and differentiates between anti-Salmonella typhi (S. typhi) IgG and IgM in human whole blood, serum or plasma samples. A test is also available for serum and plasma sample only. This test applies lateral flow immuno-chromatography and is a tool to assist in the diagnosis of infection with S. typhi.

Summary

Typhoid fever is caused by S. typhi, a Gram-negative bacterium. World-wide an estimated 17 million cases and 600,000 associated deaths occur annually. Patients who are infected with HIV are at significantly increased risk of clinical infection with S. typhi. Evidence of H. pylori infection also presents an increase risk of acquiring typhoid fever. 1-5% of patients become chronic carriers harbouring S. typhi in the gallbladder. The clinical diagnosis of typhoid fever depends on the isolation of S. typhi from blood, bone marrow or a specific anatomic lesion. In the facilities that cannot afford to perform this complicated and time consuming procedure, Filix-Widal test is used to facilitate the diagnosis. However, many limitations lead to difficulties in the interpretation of the Widal test. In contrast, the Typhoid IgG/IgM Rapid Test is a simple and rapid laboratory test. The test simultaneously detects and differentiates the IgG and the IgM antibodies to S. typhi specific antigen in serum/plasma specimens thus aiding in the determination of current or previous exposure to the S. typhi.

Principle

The Biopanda Typhoid IgG/IgM Rapid Test Cassette is a qualitative, membrane based immunoassay for the detection of antibodies (IgG and IgM) to Salmonella typhi (S. typhi) in human whole blood, serum or plasma. The diagnostic test cassette consists of two components: an IgG component and an IgM component. The IgG line region is pre-coated with reagents for the detection of anti-S. typhi (IgG). The IgM line region is pre-coated with monoclonal anti-human IgM for detection of anti-S. typhi (IgM). During testing, specimen dispensed into the sample well of the test cassette binds with Typhoid conjugates impregnated in the reagent area, if the specimen contains anti-Typhoid antibodies. The immunocomplex thus formed migrates by capillary action. If the present antibodies in specimen are of IgG types, the immunocomplex is then captured by the pre-coated reagents on the membrane, forming a coloured IgG line, indicating an S. typhi IgG positive test result. If the present antibodies in the specimen are of IgM type, the immunocomplex would be captured on the membrane by the pre-coated anti-human IgM antibody, forming a coloured IgM line, indicating an S. typhi IgM positive test result. Absence of any T lines (IgM and IgG) indicates a negative result. A coloured control line (C) should always appear in case of a positive or a negative result. Its absence indicates invalid test results.

Storage Conditions

+4 - 8 °C





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